Recent Publications
Microglial MHC-I induction with aging and Alzheimer’s is conserved in mouse models and humans Collyn M Kellogg, Kevin Pham, Adeline H Machalinski, Hunter L Porter, Harris E Blankenship, Kyla B Tooley, Michael B Stout, Heather C Rice, Amanda L Sharpe, Michael J Beckstead, Ana J Chucair-Elliott, Sarah R Ocañas, Willard M Freeman
SK and Kv4 channels limit spike timing perturbations in pacemaking dopamine neurons (2023) Higgs MH, Jones JA, Wilson CJ, Beckstead MJ. In press, eNeuro.
Long-term methamphetamine self-administration increases mesolimbic mitochondrial oxygen consumption and decreases striatal glutathione (2023) Dominguez-Lopez S, Ahn B, Sataranatarajan K, Ranjit R, Premkumar P, Van Remmen H, Beckstead MJ. In press, Neuropharmacology. 2023 Jan 21:109436. doi: 10.1016/j.neuropharm.2023.109436.
Preservation of dendritic D2 receptor transmission in substantia nigra dopamine neurons with age (2023) Troyano Rodriguez E, Blankenship HE, Handa K, Branch SY, Beckstead MJ. Scientific Reports 13:1025. PMCID 9852430.
Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with multiple sclerosis (2023) Bhaskaran S, Kumar G, Thadathil N, Piekarz K, Jazir S, Dominguez Lopez S, Qaisar R, Walton D, Brown JL, Murphy A, Smith N, Saunders D, Beckstead MJ, Plafker S, Lewis T, Towner R, Deepa SS, Richardson A, Axtell R, Van Remmen H. Redox Biology 59:102550. PMCID 9720104.
Neurotensin release from dopamine neurons drives long-term depression of substantia nigra dopamine signaling. Tschumi CW, Blankenship HE, Sharma R, Lynch WB, Beckstead MJ (2022) Journal of Neuroscience 42: 6186-6194.
Developmental or Adult-Onset Deletion of Neurotensin Receptor-1 from Dopamine Neurons Differentially Reduces Body Weight. Perez-Bonilla P, Ramirez-Virella J, Manon P, Troyano Rodriguez E, Arriaga SK, Makela A, Bugescu R, Beckstead MJ, Leinninger GM (2022) In press, Frontiers in Neuroscience.
Alcohol and methamphetamine interactions and co-abuse. Sharpe AL, Trzeciak M, Handa K, Beckstead MJ (2022). In: Patel VB, Preedy VR (eds) Handbook of Substance Misuse and Addictions. Springer, Cham.
Repeated cocaine or methamphetamine treatment alters astrocytic CRF2 and GLAST expression in the ventral midbrain. Sharpe AL, Trzeciak M, Eliason NL, Blankenship HE, Byrd BM, Douglas PD, Freeman WM, Beckstead MJ (2022) Addiction Biology 27:e13120.
Progressive parkinsonism due to mitochondrial impairment: lessons from the MitoPark mouse model. Beckstead MJ, Howell R (2021). Review article. Experimental Neurology 341:113707.
Neurotensin receptor 1 deletion decreases methamphetamine self-administration and the associated reduction in dopamine cell firing. Dominguez-Lopez S, Sharma R, Beckstead MJ (2021) Addiction Biology 26: e12854.
Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia. Chucair-Elliott AJ, Ocanas SR, Stanford DR, Ansere V, Buettner KB, Porter H, Eliason NL, Reid J, Sharpe AL, Stout MB, Beckstead MJ, Miller B, Richardson A, Freeman WM (2020) Communications Biology 3: 693.
Female mice are resilient to age-related decline of substantia nigra dopamine neuron firing parameters. Howell RD, Dominguez-Lopez S, Ocañas SR, Freeman WM, Beckstead MJ (2020) Neurobiology of Aging 95: 195-204.
A history of ethanol drinking increases locomotor stimulation and blunts enhancement of dendritic dopamine transmission by methamphetamine. Tschumi CW, Daszkowski AW, Sharpe AL, Trzeciak M, Beckstead MJ. Addiction Biology, 2020, 25: e12763.
Translating the atypical dopamine uptake inhibitor hypothesis toward potential therapeutics for treatment of psychostimulant use disorders. Newman AH, Cao J, Keighron J, Jordan CJ, Bi GH, Liang Y, Abramyan A, Avelar AJ, Tschumi CW, Beckstead MJ, Shi L, Tanda G, Xi ZX. Neuropsychopharmacol, 2019, Neuropsychopharmacol 44: 1435-1444.
Ventral tegmental area astrocytes orchestrate avoidance and approach behavior. Gomez JA, Perkins J, Beaudoin G, Cook N, Quraishi SA, Szoeke E, Thangamani K, Tschumi CW, Wanat MJ, Maroof AM, Beckstead MJ, Rosenberg P, Paladini CA. Nat Commun, 2019, 10: 1455.
Acute and subchronic PCP attenuate D2 autoreceptor signaling in substantia nigra dopamine neurons. Piccart E, Tschumi CW, Beckstead MJ. Eur Neuropsychopharmacol, 2019, 29: 444-449.
Progressively disrupted somatodendritic morphology in dopamine neurons in a mouse Parkinson’s model. Lynch WB, Tschumi CW, Sharpe AL, Branch SY, Chen C, Ge G, Li S, Beckstead MJ. Mov Disord, 2018, 33: 1928-1937.
Antagonism of Neurotensin Receptors in the Ventral Tegmental Area Decreases Methamphetamine Self-Administration and Methamphetamine Seeking in Mice. Dominguez-Lopez S, Piccart E, Lynch WB, Wollet MB, Sharpe AL, Beckstead MJ. Int J Neuropsychopharmacol. 2018, 21: 361-370.
Diverse actions of the modulatory peptide neurotensin on central synaptic transmission. Tschumi CW, Beckstead MJ. Eur J Neurosci, 2019, 49: 784-793.
Neurotensin speeds inhibition of dopamine neurons through temporal modulation of GABAAand GABAB receptor-mediated synaptic input. Tschumi CW, Beckstead MJ. Neuropharmacology 2018, 131: 414-423.
Stem cell derived interneuron transplants as a treatment for schizophrenia: preclinical validation in a rodent model. Donegan JJ, Tyson JA, Branch SY, Beckstead MJ., Anderson SA, Lodge DJ. Mol Psychiatry. 2017 Oct;22(10):1492-1501.
Systemic PD149163, a neurotensin receptor 1 agonist, decreases methamphetamine self-administration in DBA/2J mice without causing excessive sedation. Sharpe AL, Varela E, Beckstead MJ. PLoS One. 2017 Jul 7;12(7):e0180710. doi: 10.1371/journal.pone.0180710. eCollection 2017.
Atypical dopamine transporter inhibitors R-modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons. Avelar AJ, Cao J, Newman AH, Beckstead MJ. Neuropharmacology. 2017 Sep 1;123:410-419. doi: 10.1016/j.neuropharm.2017.06.016. Epub 2017 Jun 15.
Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice. McCall NM, Kotecki L, Dominguez-Lopez S, Marron Fernandez de Velasco E, Carlblom N, Sharpe AL, Beckstead MJ., Wickman K. Neuropsychopharmacology. 2017 Feb;42(3):707-715. doi: 10.1038/npp.2016.138. Epub 2016 Jul 29.
Dopaminergic neurons exhibit an age-dependent decline in electrophysiological parameters in the MitoPark mouse model of Parkinson’s disease. Branch SY, Chen C, Sharma R, Lechleiter JD, Li S and Beckstead MJ. J Neurosci. 2016 Apr 6;36(14):4026-37.
Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. Piccart E, Courtney NA, Branch SY, Ford CP, Beckstead MJ. J Neurosci. 2015 Aug 5;35(31):11144-52. doi: 10.1523/JNEUROSCI.3816-14.2015.
Physiological and behavioral effects of amphetamine in BACE1(-/-) mice. Paredes RM, Piccart E, Navaira E, Cruz D, Javors MA, Koek W, .Beckstead MJ., Walss-Bass C. Genes Brain Behav. 2015 Jun;14(5):411-8. doi: 10.1111/gbb.12222. Epub 2015 May 21.
Methamphetamine self-administration in mice decreases GIRK channel-mediated currents in midbrain dopamine neurons. Sharpe AL, Varela E, Bettinger L, Beckstead MJ. Int J Neuropsychopharmacol. 2014 Oct 31;18(5).
Aging decreases L-type calcium currents and pacemaker firing fidelity in substantia nigra dopamine neurons. Branch SY, Sharma R and Beckstead MJ. J Neurosci. 2014 Jul 9;34(28):9310-8.
Food restriction increases glutamate receptor-mediated burst firing of dopamine neurons. Branch SY, Goertz RB, Sharpe AL, Pierce J, Roy S, Ko D, Paladini CA, Beckstead MJ. J Neurosci. 2013 Aug 21;33(34):13861-72.
Selected Publications
CRF enhancement of GIRK channel-mediated transmission in dopamine neurons. Beckstead MJ., Gantz SC, Ford CP, Stenzel-Poore MP, Phillips PE, Mark GP, Williams JT. Neuropsychopharmacology. 2009 Jul;34(8):1926-35. doi: 10.1038/npp.2009.25. Epub 2009 Mar 11.
Long-term depression of a dopamine IPSC. Beckstead MJ., Williams JT. J Neurosci. 2007 Feb 21;27(8):2074-80.
Vesicular dopamine release elicits an inhibitory postsynaptic current in midbrain dopamine neurons. Beckstead MJ., Grandy DK, Wickman K, Williams JT. Neuron. 2004 Jun 24;42(6):939-46.